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The progression of CP is clinically observable, starting with acinar cell dysfunction, followed by beta-cell dysfunction, and lastly, a decrease in alpha-cell function which signifies the end stage of the disease

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These data have been used to develop and validate various biological effects and toxicity models used to predict toxicity (especially to new and understudied species) and have been of use both in the National Resource Damage Assessment (NRDA) process and in oil spill decision making to determine the best response option